Publications by our Researchers
Please see below for a selection of publications by our researchers. Please
check back frequently to see more publications being added to this page.
Recognition of depression in bipolar disorder: leveraging cohort and person-specific knowledge
Presented at Interspeech, September 8-12, 2016, San Francisco. Soheil Khorram, John Gideon, Melvin McInniy, Emily Mower Provost
The Splice Is Right: ANK3 and the Control of Cortical Circuits
Biological Psychiatry, Published: 15 August 2016, 80(4):263-5, DOI: 10.1016/j.biopsych.2016.06.006 Nelson AD, Jenkins PM
The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample
BMC Psychiatry, Published: 5 May 2016, DOI: 10.1186/s12888-016-0732-x
Ketil J. Oedegaard, Martin Alda, Anit Anand, Ole A. Andreassen, Yokesh Balaraman, Wade H. Berrettini, Abesh Bhattacharjee, Kristen J. Brennand, Katherine E. Burdick, Joseph R. Calabrese, Cynthia V. Calkin, Ana Claasen, William H. Coryell, David Craig, Anna DeModena, Mark Frye, Fred H. Gage, Keming Gao, Julie Garnham, Elliot Gershon, Petter Jakobsen, Susan G. Leckband, Michael J. McCarthy, Melvin G. McInnis, Adam X. Maihofer, Jerome Mertens, Gunnar Morken, Caroline M. Nievergelt, John Nurnberger, Son Pham, Helle Schoeyen, Tatyana Shekhtman, Paul D. Shilling, Szabolcs Szelinger, Bruce Tarwater, Jun Yao, Peter P. Zandi and John R. Kelsoe
Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder
BMC Psychology, Published: 2 April 2016, DOI: 10.1186/s40359-016-0118-3
Stephanie A. Flowers, Kelly A. Ryan, Zongshan Lai, Melvin G. McInnis and Vicki L. Ellingrod
Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling
Journal of Affective Disorders, July 15, 2016, Volume 199, Pages 87–94. DOI: 10.1016/j.jad.2016.04.016
Kelly A. Ryan, Shervin Assari, Bethany D. Pester, Kristin Hinrichs, Kaley Angers, Amanda Baker, David F. Marshall, Deborah Stringea, Erika F.H. Saunders, Masoud Kamali, Melvin G. McInnis, Scott A. Langenecker
Mood State Prediction from Speech of Varying Acoustic Quality for Individuals with Bipolar Disorder
Presented at the 2016 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), March 20-25, 2016.
John Gideon, Emily Mower Provost, Melvin McInnis
A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report
Journal of Affective Disorders, March 1, 2016, 192, 212-218. DOI: 10.1016/j.jad.2015.12.036
Noreen A. Reilly-Harrington, Richard C. Shelton, Masoud Kamali, Dustin J. Rabideau, Leah W. Shesler, Madhukar H. Trivedi, Susan L. McElroy, Louisa G. Sylvia, Charles L. Bowden, Terence A. Ketter, Joseph R. Calabrese, Michael E. Thase, William V. Bobo, Thilo Deckersbach, Mauricio Tohen, Melvin G. McInnis, James H. Kocsis, Alexandra K. Gold, Vivek Singh, Daniel M. Finkelstein, Gustavo Kinrys, Andrew A. Nierenberg
Deficient inhibitory control as an outcome of childhood trauma
Psychiatric Research, December 11, 2015. DOI: 10.1016/j.psychres.2015.12.013
David F. Marshall, Alessandra M. Passarotti, Kelly A. Ryan, Masoud Kamali, Erika F.H. Saunders, Bethany Pester, Melvin G. McInnis, Scott A. Langenecker
Neurodevelopmental origins of bipolar disorder: iPSC models
Molecular and Cellular Neuroscience, December 1, 2015. DOI:10.1016/j.mcn.2015.11.006
K. Sue O'Shea and Melvin G. McInnis
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Nature, November 5, 2015, 527, 95-99. DOI: 10.1038/nature15526
Jerome Mertens, Qiu-Wen Wang, Yongsung Kim, Diana X. Yu, Son Pham, Bo Yang, Yi Zheng, Kenneth E. Diffenderfer, Jian Zhang, Sheila Soltani, Tameji Eames, Simon T. Schafer, Leah Boyer, Maria C. Marchetto, John I. Nurnberger, Joseph R. Calabrese, Ketil J. Ødegaard, Michael J. McCarthy, Peter P. Zandi, Martin Alba, Caroline M. Nievergelt, The Pharmacogenomics of Bipolar Disorder Study, Shuangli Mi, Kristen J. Brennand, John R. Kelsoe, Fred H. Gage & Jun Yao
Longitudinal impact of a collaborative care model on employment outcomes in bipolar disorder
Journal of Affective Disorders, December 1, 2015, Volume 188 , 239 - 242. DOI: 10.1016/j.jad.2015.08.052
Kelly A. Ryan, Daniel Eisenberg, Hyungjin M. Kim, Zongshan Lai, Melvin McInnis, Amy M. Kilbourne
Assessment of First and Second Degree Relatives of Individuals With Bipolar Disorder Shows Increased Genetic Risk Scores in Both Affected Relatives and Young At-Risk Individuals
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, July 16, 2015. 168 (7), 617-629. DOI: 10.1002/ajmg.b.32344
Janice M. Fullerton, Daniel L. Koller, Howard J. Edenberg, Tatiana Foroud, Hai Liu, Anne L. Glowinski, Melvin G. McInnis, Holly C. Wilcox, Andrew Frankland, Gloria Roberts, Peter R. Schofield, Philip B. Mitchell, John I. Nurnberger, and Bipolar High Risk Study Group, BiGS Consortium
Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales
Journal of Psychiatric Research, 14 June, 2015, 68 (2015) 61-67, doi:10.1016/j.jpsychires.2015.06.001
Simon J. Evans, Shervin Assari, Gloria J. Harrington, Ya-Wen Chang, Charles F. Burant, Melvin G. McInnis
Longitudinal studies: An essential component for complex psychiatric disorders
Neuroscience Research, 5 June 2015, doi:10.1016/j.neures.2015.05.004
Melvin G. McInnis, John F. Greden
Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States
Neural Plasticity, Volume 2015 (2015), Article ID 939780, 6 pages. 2015. doi:10.1155/2015/939780
A. R. Prossin, R. H. Yolken, M. Kamali, M. M. Heitzeg, J. B. Kaplow, W. H. Coryell, and M. G. McInnis
The effect of poor sleep quality on mood outcome differs between men and women: A longitudinal study of bipolar disorder
Journal of Affective Disorders, 15 July 2015. Volume 180. Pages :90-96. doi:10.1016/j.jad.2015.03.048
Erika F.H. Saunders, Julio Fernandez-Mendoza, Masoud Kamali, Shervin Assari, Melvin G. McInnis
Shared dimensions of performance and activation dysfunction in cognitive control in females with mood disorders
Brain, May 2015, 138 (5) 1424-1434; DOI: 10.1093/brain/awv070
Kelly A. Ryan , Erica L. Dawson , Michelle T. Kassel , Anne L. Weldon , David F. Marshall , Kortni K. Meyers , Laura B. Gabriel , Aaron C. Vederman , Sara L. Weisenbach , Melvin G. McInnis , Jon-Kar Zubieta , Scott A. Langenecker
Complexity of Illness and Adjunctive Benzodiazepine Use in Outpatients With Bipolar I or II Disorder
Journal of Clinical Psychopharmacology, February 2015. 35(1):68-74. doi: 10.1097/JCP.0000000000000257
Bobo WV, Reilly-Harrington NA, Ketter TA, Brody BD, Kinrys G, Kemp DE, Shelton RC, McElroy SL, Sylvia LG, Kocsis JH, McInnis MG, Friedman ES, Singh V, Tohen M, Bowden CL, Deckersbach T, Calabrese JR, Thase ME, Nierenberg AA, Rabideau DJ, Schoenfeld DA, Faraone SV, Kamali M.
Induced Pluripotent Stem Cell (iPSC) Models of Bipolar Disorder
Neuropsychopharmacology Reviews, January 2015. 40:248–249; doi:10.1038/npp.2014.221
Sue O'Shea and Melvin G McInnis
Medical burden in bipolar disorder: findings from the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study (Bipolar CHOICE)
Bipolar Disorders, August 2014. DOI: 10.1111/bdi.12243
Sylvia LG, Shelton RC, Kemp DE, Bernstein EE, Friedman ES, Brody BD, McElroy SL, Singh V,Tohen M, Bowden CL, Ketter TA, Deckersbach T, Thase ME, Reilly-Harrington NA, Nierenberg AA,Rabideau DJ, Kinrys G, Kocsis JH, Bobo WV, Kamali M, McInnis MG, Calabrese JR
Openness Predicts Cognitive Functioning in Bipolar Disorder
Journal of Affective Disorders, July 2014. DOI: 10.1016/j.jad.2014.06.038
Deborah Stringer, David Marshall, Bethany Pester, Amanda Baker, Scott A. Langenecker, Kaley Angers, Nicole Frazier, Christopher Archer, Masoud Kamali, Melvin McInnis, Kelly A. Ryan
The Arabic Diagnostic Interview for Genetic Studies: aDIGS: Psychometric Properties
The Arab Journal of Psychiatry (2014) Vol. 25, No. 1 Page (18–23)(dio: 10.12816/0004111)
Elie G. Karam, Ziad Kronfol, Mariana Salamoun, Lynn Farah, Marie Therese Nacouzi,
Stephanie Loukieh, Yasmeen M Assad, Grace Aranki, Melvin G McInnis
Dietary Intake and Plasma Metabolomic Analysis of Polyunsaturated Fatty Acids in Bipolar Subjects Reveal Dysregulation of Linoleic Acid Metabolism
Journal of Psychiatric Research, June 2014. DOI: 10.1016/j.jpsychires.2014.06.001
Simon J. Evans, PhD, Rachel N. Ringrosea, Gloria J. Harrington, Peter Mancuso, Charles F. Burantc, Melvin G. McInnis
The Role of Social Relationships in Bipolar Disorder: A Review
Psychiatry Research, June 2014. DOI: 10.1016/j.psychres.2014.05.047
Sarah Greenberg, Katherine L. Rosenblum, Melvin G. McInnis, Maria Muzik
Ecologically Valid Long-term Mood Monitoring of Individuals with Bipolar Disorder Using Speech
Presented at the 2014 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), May 4-9, 2014
Zahi N. Karam, Emily Mower Provost, Satinder Singh, Jennifer Montgomery, Christopher Archer, Gloria Harrington, Melvin G. Mcinnis
Gender Differences, Clinical Correlates, and Longitudinal Outcome of Bipolar Disorder With Comorbid Migraine
Clinical Pyschological Science, April 2014. doi: 10.4088/JCP.13m08623
Erika F. H. Saunders, MD; Racha Nazir, MD; Masoud Kamali, MD; Kelly A. Ryan, PhD; Simon Evans, PhD; Scott Langenecker, PhD; Alan J. Gelenberg, MD; and Melvin G. McInnis, MD
Regulating the High: Cognitive and Neural Processes Underlying Positive Emotion Regulation in Bipolar I Disorder
Clinical Pyschological Science, April 9, 2014. doi:10.1177/2167702614527580
Jiyoung Park, Özlem Ayduk, Lisa O'Donnell, Jinsoo Chun, June Gruber, Masoud Kamali, Melvin G. McInnis, Patricia Deldin, and Ethan Kross
Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients
Translational Psychiatry (2014) 4, e375; doi:10.1038/tp.2014.12
H.M. Chen, C.J. DeLong, M. Bame, I. Rajapakse, T.J. Herron, M.G. McInnis, and K.S. O’Shea
The double burden of age and disease on cognition and quality of life in bipolar disorder
International Journal of Geriatric Psychiatry, February 2014. doi: 10.1002/gps.4084
Sara L. Weisenbach, David Marshall, Anne L.Weldon, Kelly A. Ryan, Aaron C. Vederman, Masoud Kamali, Jon-Kar Zubieta, Melvin G. McInnis, and Scott A. Langenecker.
Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE): a pragmatic trial of complex treatment for a complex disorder
Clin Trials. 2014 Feb;11(1):114-27. doi: 10.1177/1740774513512184.
Nierenberg AA1, Sylvia LG, Leon AC, Reilly-Harrington NA, Shesler LW, McElroy SL, Friedman ES, Thase ME, Shelton RC, Bowden CL, Tohen M, Singh V, Deckersbach T, Ketter TA, Kocsis JH, McInnis MG, Schoenfeld D, Bobo WV, Calabrese JR; Bipolar CHOICE Study Group.
Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics
Cardiovascular Psychiatry and Neurology, vol. 2013, Article ID 596945, 8 pages, 2013. doi:10.1155/2013/596945
Kyle J. Burghardt, Kristen N. Gardner, Joshua W. Johnson, and Vicki L. Ellingrod,
Emotion perception and executive functioning predict work status in euthymic bipolar disorder
Psychiatry Research, Volume 210, Issue 2, 15 December 2013, Pages 472–478
Kelly A. Ryan, Aaron C. Vederman, Masoud Kamali, David Marshall, Anne L. Weldon, Melvin G. McInnis, Scott A. Langenecker
Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population.
Bipolar Disorder. 2013 Dec 13. doi: 10.1111/bdi.12160.
Bly MJ1, Taylor SF, Dalack G, Pop-Busui R, Burghardt KJ, Evans SJ, McInnis MI, Grove TB, Brook RD, Zöllner SK, Ellingrod VL.
Can P300 distinguish among schizophrenia, schizoaffective and bipolar I disorders? An ERP study of response inhibition
Schizophrenia Research, Volume 151, December 2013, Pages 175–184
J. Chun, Z.N. Karam, F. Marzinzik, M. Kamali, L. O'Donnell, I.F. Tso, T.C. Manschreck, M. McInnis, P.J. Deldin
Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder.
Journal of Affective Disorders, 151(2), 722-727. (2013).
Sylvia, L. G., Tohen, M., Mcinnis, M. G., Kamali, M., Friedman, E. S., Kocsis, J. H., et al.
Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population
Bipolar Disorders, 1 August 2013, doi: 10.1111/bdi.12160
Michael J. Bly, Stephan F. Taylor, Gregory Dalack, Rodica Pop-Busui, Kyle J. Burghardt, Simon J. Evans, Melvin McInnis, Tyler B. Grove, Robert D. Brook, Sebastian K. Zoellner, and Vicki L. Ellingrod
Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events
International Journal of Bipolar Disorders 2013, 1:16 (doi:10.1186/2194-7511-1-13)
Erika F.H. Saunders, Danielle M. Novick, Julio Fernandez-Mendoza, Masoud Kamali, Kelly A. Ryan, Scott A. Langenecker, Alan J. Gelenberg and Melvin G. McInnis
Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders
International Journal of Bipolar Disorders 2013, 1:13 (doi:10.1186/2194-7511-1-13)
Andrew Jen, Erika F.H. Saunders, Rollyn M. Ornstein, Masoud Kamali and Melvin G. McInnis
C9ORF72 expansion in a family with bipolar disorder
Bipolar Disorders, 15(3), 326-332. (2013)
Meisler, M. H., Langenecker, S. A., Mcinnis, M. G., Lieberman, A. P., Albin, R. L., Kamali, M., et al.
A Pilot Study Investigating Tumor Necrosis Factor-[alpha] as a Potential Intervening Variable of Atypical Antipsychotic-Associated Metabolic Syndrome in Bipolar Disorder.
Therapeutic Drug Monitoring. 35(2):194-202, April 2013.
Prossin AR, Zalcman SS, Evans SJ, McInnis MG, Ellingrod VL.
Gene expression alterations in bipolar disorder postmortem brains
Bipolar Disorders, Volume 15, Issue 2, March 2013, Pages 177-187
Haiming Chen, Nulang Wang, Xin Zhao, Christopher A. Ross, K. Sue O’Shea, Melvin G. McInnis
The Influence of the Brain-Derived Neurotropic Factor Val66Met -Genotype and HMG-CoA Reductase Inhibitors on Insulin Resistance in the Schizophrenia and Bipolar Populations
Clinical and Translational Science, 5: 486–490. doi: 10.1111/cts.12001
Burghardt, K.J., Pop-Busui, R., Bly, M.J., Grove, T.B., Taylor, S.F. and Ellingrod, V.L. (2012),
Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder
Psychiatry Research, Volume 200, Issues 2–3, 30 December 2012, Pages 252–257
David F. Marshall, Sara J. Walker, Kelly A. Ryan, Masoud Kamali, Erika F.H. Saunders, Anne L. Weldon, Kenneth M. Adams, Melvin G. McInnis, Scott A. Langenecker
Reduced emotion processing efficiency in healthy males relative to females
Soc Cogn Affect Neurosci (2014) 9 (3): 316-325 first published online November 29, 2012 doi:10.1093/scan/nss137
Sara L. Weisenbach, Lisa J. Rapport, Emily M. Briceno, Brennan D. Haase, Aaron C. Vederman, Linas A. Bieliauskas, Robert C. Welsh, Monica N. Starkman, Melvin G. McInnis, Jon-Kar Zubieta, and Scott A. Langenecker
Association of plasma omega-3 and omega-6 lipids with burden of disease measures in bipolar subjects
Psychiatric Research, Volume 46, Issue 11, November 2012, Pages 1435–1441
Simon J. Evans, Masoud Kamali, Alan R. Prossin, Gloria J. Harrington, Vicki L. Ellingrod, Melvin G. McInnis, Charles F. Burant
Modality-specific alterations in the perception of emotional stimuli in Bipolar Disorder compared to Healthy Controls and Major Depressive Disorder
Cortex, Volume 48, Issue 8, September 2012, Pages 1027–1034
Aaron C. Vederman, Sara L. Weisenbach, Lisa J. Rapport, Hadia M. Leon, Brennan D. Haase, Lindsay M. Franti, Michael-Paul Schallmo, Erika F.H. Saunders, Masoud M. Kamali, Jon-Kar Zubieta, Scott A. Langenecker, Melvin G. McInnis
Differential executive functioning performance by phase of bipolar disorder
Kelly A. Ryan, Aaron C. Vederman, E. Michelle McFadden, Anne L. Weldon, Masoud Kamali, Scott A. Langenecker and Melvin G. McInnis
Fats and Factors: Lipid Profiles Associate with Personality Factors and Suicidal History in Bipolar Subjects
Simon J. Evans, Alan R. Prossin, Gloria J. Harrington, Masoud Kamali, Vicki L. Ellingrod, Charles F. Burant, Melvin G. McInnis
2011 - 2007
Associations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder
Journal of Affective Disorders, Available online 10 December 2011
Masoud Kamali, Erika F.H. Saunders, Alan R. Prossin, Christine B. Brucksch, Gloria J. Harrington, Scott A. Langenecker, Melvin G. McInnis
A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
BMC Systems Biology, 4(1), 158. (2010).
Mceachin, R. C., Chen, H., Sartor, M. A., Saccone, S. F., Keller, B. J., Prossin, A. R., et al.
Cognitive phenotypes in bipolar disorder
Journal of Affective Disorders, Volume 122, Issue 3, May 2010, Pages 285-293(doi:10.1016/j.jad.2009.08.018)
Scott A. Langenecker, Erika F.H. Saunders, Allison M. Kade, Michael T. Ransom, Melvin G. McInnis
Suggestive linkage at 9p22 in bipolar disorder weighted by alcohol abuse
Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5; 150B(8):1133-8.
Saunders EF, Zhang P, Copeland JN, Mclnnis MG, Zoellner S.
2009 Wiley-Liss, Inc. PMID: 19259988
Bayesian EM Algorithm for Scoring Polymorphic Deletions From SNP Data and Application to a Common CNV on 8q24
Genet. Epidemiol. 33:357–368, 2009.
Sebastian Zoellner, 1–4; Gang Su, 3; William C. L. Stewart, 1,4; Yi Chen, 1; Melvin G McInnis, 2; and Margit Burmeister, 2–5
1 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
2 Department of Psychiatry, University of Michigan, Ann Arbor, Michigan
3 Bioinformatics Program, University of Michigan, Ann Arbor, Michigan
4 Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan
5 Department of Human Genetics, University of Michigan, Ann Arbor, Michigan
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7501-6. Epub 2009 Apr 28.
Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M.
Modeling gene-by-environment interaction in comorbid depression with alcohol
use disorders via an integrated bioinformatics approach
Article appeared in BioData Mining 2008, 1:2 (doi:10.1186/1756-0381-1-2)
© 2008 McEachin et al; licensee BioMed Central Ltd.
Richard C. McEachin, Benjamin J. Keller, Erika F.H. Saunders, Melvin G. McInnis
Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health Bipolar sample
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 147B, Issue 1, pages 18–26, 5 January 2008
Article first published online: 24 MAY 2007
Erika H. Saunders, Laura J. Scott, Melvin G. McInnis, Margit Burmeister