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Phase Specific Variability in Bipolar Disorder: Performance, Neuroimaging, and
Every Day Functioning

This study seeks to examine patterns of brain activation and cognitive performance associated with different mood states in the bipolar illness and how this relationship is related to every day functioning (household maintenance, social/family functioning, vocational functioning, level of independent living). To do this, patients with bipolar illness will complete cognitive tasks while undergoing functional magnet resonance imaging scans (fMRI) scans during two different mood states, once when they are euthymic and once during a mania/hypomania episode. Self-report ratings of every day functioning will be collected at both time points. The goal of this study is to better understand the neurobiology associated with mood shifts which could help focus intervention treatments to improve every day functioning. Further, this study may help to improve our ability to recognize the early problematic mood shifts.

Volunteers who would like to participate in this research must first be a participant in the Prechter Longitudinal Study of Bipolar Disorder. To learn more about participating in research, please contact a research associate at 1-877-UM GENES (1-877-864-3637) or bpresearch@umich.edu and reference the study: “Biphase”

This study has received approval from IRBMED: HUM00042114